
Vacation rentals in Defiance
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Defiance
Guests agree: these stays are highly rated for location, cleanliness, and more.

Route 66 Railroad Shanty, a cozy artsy small space
This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Honey Ridge Hideaway- Historic Home with Vineyard
Explore Augusta while staying at our historic home set on 7 acre private Vineyard. Honey Ridge Hideaway is located up on a hill overlooking the Missouri River. Our home is walking distance to downtown Augusta. Some town favorites are the farm to table restaurant, wineries, carriage rides, spa and antique shopping. Augusta also offers a local trolley to help navigate your wineries tours. This gorgeous home comfortably sleeps 10 offering the amenities of a hotel with the comfort & privacy of home.

Pinehaven Place - Pet friendly home in Labadie, MO
Home was new in 2013. Very dog friendly with dog doors leading to fenced areas, but great for families without pets, too. Close to Purina Farms, Six Flags, Wineries, St Albans and the Hawthorne Inn restaurant. Handmade benches in each bedroom by Missouri River Timber for suitcases. There is satellite TV, blue-ray player, and an Xbox One. Warmer months we have a gas grill and picnic bench on the back patio, and deer and wild turkey roam the fields. We hope to see you at "Pinehaven Place".

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!
DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Romantic Augusta Cottage-Relax & get away!
This cottage is designed to strengthen and refresh couples looking for a getaway from busy life. Relax in the comfortable Living room or prepare a meal in the recently updated fully furnished kitchen. Enjoy your nights in the spacious bedroom furnished with a California King sized bed and TV in the room. Enjoy the private hot tub just steps from the door or use the BBQ pit to create a meal to enjoy together. Area restaurants, wineries & golf are just minutes away! You are sure to enjoy!

Treehouse Spa Suite
Treehouse Day Spa is nestled on 3 wooded acres in St.Charles County. There is a subdivision next to me but I have my trees!!! Get away from it all while being close to it all at the same time. Augusta wineries, Main Street St. Charles and the Streets of Cottleville are all within minutes of the location! There are two rental units in the treehouse: The spa suite and the penthouse. They each have a separate entrance and are private spaces. Recharge your battery! Regroup Relax Refresh

Serene & Cozy Cabin + LAKE! Near Purina & SixFlags
Are you looking for that perfect little spot for your romantic getaway? Maybe a girls trip, a weekend of fishing with the boys, or just need some family fun on the water? Then come check out our cabin and spot on the lake! You can get away from it all & still be close to everything STL has to offer. This home has been completely updated from top to bottom and you’ll have access to a 12 acre lake, perfect for soaking up some fun in the sun. Fish, swim, kayak, play - you deserve it :)

Out On A Limb Treehouse
A unique Treehouse, 6 miles from Hermann, MO, offers a luxury escape with stunning views and sunsets. Perched on stilts by Daniel Boone Conservation Area, enjoy tranquility, hiking, and wildlife. Relax in a king-size bed beneath skylights, soak in a tub, or unwind in the hot tub and firepit. Just a mile from the Katy Trail, perfect for cycling or relaxing. Explore Hermann’s wineries, shops, and events. Transportation available from Hermann Trolley, Uber & Lyft. Sleeps 2 adults.

Modern Barnhouse Retreat
🏡 Relax and enjoy the incredible views on this home 🍃 Close to Katy Trail, Good News Brewery, Mount Pleasant Winery & Augusta Winery. Shuttle services also available! This spacious home is in the heart of wine country. Take some time with your friends, family or partner to unwind and put your worries behind you. This home offers enough room for 4 people to comfortably stay while also creating an intimate ambiance if you wish to enjoy a romantic weekend in wine country.

Serenity Valley• Secluded Escape • No Cleaning Fee
Discover Serenity in this 675 sq ft Studio cottage on a private wooded lot. Cozy space with 1 queen bed & optional sofa queen bed for up to 4 guests. Relax on the patio, enjoy a bubble bath in the vintage clawfoot tub, or take in the panoramic woods view on the couch. Amenities include WIFI, washer/dryer, fully stocked kitchen, pack&play. Just 60 mins from downtown STL, 15 mins from Washington, 20 minutes from Six Flags. Your tranquil escape awaits! No pets allowed.

2nd Street Loft - Riverview
Complete Rehab, this historic 1883 storefront building hosts a well known artist and his gallery on the 1st floor. Above is your "loft space" close to wineries, Amtrak, featuring great views of the Missouri River. You’ll love this Downtown Washington location because of the walkable shops, bars, and restaurants many in historic buildings. The loft is great for couples, solo adventurers, and business travelers who can walk a flight of stairs.

Augusta Haus
This early 1850's Augusta home has been lovingly revitalized to help those who stay here capture the essence of Augusta. While we have highlighted the craftsmanship of the original builder, we have also incorporated our vision of a comfortable historic home in the very heart of Missouri wine country. Great for couples as well as those traveling with friends or children. Relax and enjoy our Augusta Haus!
Popular amenities for Defiance vacation rentals
Other great vacation rentals in Defiance

‘The Merlot Bungalow’ Defiance Tiny Home on Trail

The Blake Cottage Wine Country Home

Corner River View Loft - Main St Washington 102

American Bounty: Upper Patio Access

The Reserve Guest Cottage

Farm Stay+Eclectic Vintage+Fresh Eggs+EV Charge

'The Ruebling House' Historic Defiance Apartment!

Downtown Getaway
Destinations to explore
- Nashville Vacation rentals
- Chicago Vacation rentals
- Indianapolis Vacation rentals
- St. Louis Vacation rentals
- Louisville Vacation rentals
- Memphis Vacation rentals
- Branson Vacation rentals
- Kansas City Vacation rentals
- Bentonville Vacation rentals
- Eureka Springs Vacation rentals
- Des Moines Vacation rentals
- Downtown Chicago Vacation rentals
- Busch Stadium
- Central West End
- Six Flags St. Louis
- Saint Louis Zoo
- Enterprise Center
- The Dome at America's Center
- St. Louis Aquarium at Union Station
- City Museum
- Gateway Arch
- Missouri Botanical Garden
- Washington University in St Louis
- Meramec State Park
- Hidden Valley Ski Resort
- Forest Park
- Gateway Arch National Park
- Castlewood State Park
- Saint Louis University
- Meramec Caverns
- The Pageant
- Saint Louis Science Center
- Cathedral Basilica of Saint Louis
- Saint Louis Art Museum
- Soulard Farmers Market
- Westport Plaza





