Vacation rentals in Clayton County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Clayton County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

Apartment in McGregor

4.96 out of 5 average rating, 237 reviews

Cave Courtyard Guest Studio

The Cave Courtyard Guest Studio. A relaxing getaway located on the ground floor of an 1848 historic building just 1 block from the Mississippi River and unique shops and eateries. Sleeps 4 with a queen bed and daybed with pull out trundle, private entrance, private bath with shower, kitchenette with microwave and mini fridge, internet, cable tv and air-conditioning. There is also a private courtyard located below unique cliff side caves. Some food items are also supplied. Adults only-no pets.

Mar 16 – 23

R1,516 ZAR per night

Guest favorite

Home in Marquette

4.96 out of 5 average rating, 159 reviews

1884 Red Brick Cottage

Due to the COVID-19 pandemic, we are taking extra steps to ensure the safety of our renters. Step back in time to a quiet small town in Iowa, nestled within the hills of the driftless area. Time seems to stand still while you're here. The 1884 Red Brick Cottage offers 3+ Bedrooms in a peaceful neighborhood, close to riverfront activities, casino and downtown Marquette. Spacious backyard and sideyard, house is fully furnished and includes a firepit and gas grill for evening outdoor activities.

Nov 4 – 11

R2,178 ZAR per night

Superhost

Home in Guttenberg

4.78 out of 5 average rating, 37 reviews

(The Riverside Retreat) Cozy, Newly Remodeled Home

Whether you’re looking for your next weekend getaway as a couple or planning a fishing/hunting trip with the boys, this is the place for you! This newly remodeled, cozy little home sitting near the railroad is conveniently, and centrally located just minutes away from the mighty Mississippi as well as Guttenberg’s vibrant, historical downtown center. This Airbnb can sleep 3-4 comfortably with a queen bed and a twin bed, and more with two sofas accommodating for sleep, as well as a foldout futon.

Sep 24 – Oct 1

R1,500 ZAR per night

Guest favorite

Home in Prairie du Chien

4.94 out of 5 average rating, 123 reviews

The Bunk House

Book your stay with The Bunk House! Great for large groups, cozy weekends or family getaways. Features include free WiFi, TV/DVD player/DVDs and board games available, fully furnished kitchen, bathrooms, extra makeup stations and free laundry. The Bunk House is conveniently located within walking distance of beautiful downtown Prairie Du Chien~Great bars, restaurants, shopping, farmers/flea markets, water fun, historical sites and so much more. I’d love to help make your stay a memorable one!

Nov 8 – 15

R1,865 ZAR per night

Guest favorite

Cottage in Clayton

4.97 out of 5 average rating, 101 reviews

2-Bedroom Creekside Cottage Near the Mississippi

Get away and relax at this creekside cottage tucked away in the bluffs of the Mississippi. The cottage has a peaceful bubbling creek running beside it, sip your morning coffee on the screened in porch, enjoy nature and unwind. The Mighty Mississippi is .2 miles from the cottage. The tiny town of Clayton, Iowa has 2 restaurants that are open on the weekends. Nearby towns are filled with fun, unique shops. Many hiking trails and fishing spots are nearby! Pikes Peak is 8 miles from the cabin!

Apr 10 – 17

R2,090 ZAR per night

Guest favorite

Home in Guttenberg

4.98 out of 5 average rating, 56 reviews

“The Depot” 2 bed 1 bath house close to river

located next to the tracks this 1000 sq ft home is 3 blocks from the river. Extensively insulated and remolded. Central air, Fully furnished, WiFi, washer and dryer, bean bag boards, outside patio with fire pit and grill. Living room has seating for 6, master has a pillow top queen bed, 2nd bedroom has 2 pillow top twin beds. Roku TVs in the living room and both bedrooms. Plenty of Parking outside for at least 3 trucks with trailers with an outdoor water hose for cleaning your boat off.

Aug 18 – 25

R1,870 ZAR per night

Guest favorite

Cottage in Prairie du Chien

4.96 out of 5 average rating, 190 reviews

Modern Cottage on the Mississippi River

Modern, private cottage with hardwood floors, new furniture and an opportunity to disconnect from everyday life. A quiet oasis located on the Mississippi River with direct access to the river for boating, swimming, fishing, bird watching and leaf looking. Open concept kitchen with new appliances and a 3-season porch perfect for watching the sunrise/sunset. The property has a private beach, boat dock, kayaks and a canoe for your use. There is a fire pit, fireplace and air conditioning.

May 24 – 31

R5,778 ZAR per night

Guest favorite

Tiny home in Monona

4.95 out of 5 average rating, 150 reviews

Creekside-water and nature lovers paradise

Is this Heaven? Maybe. Are you looking for a fun getaway for yourself, family, or friends? Well, look no further. Our place is ready for you to make lifelong memories. Create and tell stories while sitting under the stars next to the crackling campfire. Do your morning yoga by the babbling stream. Hike the trails. Soak up the sun on the sandy beach while listening to the waterfall. Laugh and splash your kiddos in our pond. Beach chairs, sand toys, floaties, kayaks, and more.

Aug 22 – 29

R1,978 ZAR per night

Guest favorite

Apartment in Clayton

4.92 out of 5 average rating, 118 reviews

Cozy Apartment Steps from the Mighty Mississippi

Disconnect from the daily grind and enjoy a getaway in this welcoming one bedroom apartment, steps away from the Mighty Mississippi. Located in Clayton, Iowa, Located within walking distance of two delicious restaurants and a boat launch., and only 1/2 hour from the Casino Queen, local wineries, Pikes Peak State Park, as well as the historic communities of Elkader, IA and Prairie Du Chien, WI. Need more space? I also offer a two bedroom apartment: www. airbnb. com/rooms/43979345

Jan 4 – 11

R2,217 ZAR per night

Guest favorite

Home in McGregor

4.95 out of 5 average rating, 163 reviews

McGregor Manor Victorian Getaway

Welcome to our beautiful Victorian home located in the quaint town of McGregor, Iowa. Our 2,800 sq. ft. home was built during McGregor's early years as a Mississippi River boom town. Attractions include antiquing, biking, fishing, hunting, hiking and boating! We're a short drive from Pike's Peak, Effigy Mounds and Prairie du Chien, WI. Entire access of the home, each bedroom consists of en suite or attached bath. Fully furnished and decorated. See below for more details.

Mar 26 – Apr 2

R3,704 ZAR per night

Guest favorite

Apartment in Elkader

4.92 out of 5 average rating, 48 reviews

The Jude

Loft-like 1 BR/1 BA 2nd floor apt. located in historic Elkader, IA. This 1901 building has many neat architectural features including high ceilings, arched windows overlooking Main St. and wood floors. Large combo living and dining area, and full kitchen. BR has queen bed; also 1 twin air mattresse avail. upon request. Bumper pool table. Free parking. Fantastic DOWNTOWN location close to everything! Enjoy the Turkey River and beautiful Clayton County!!!

Apr 5 – 12

R2,374 ZAR per night

Guest favorite

Apartment in Guttenberg

4.9 out of 5 average rating, 59 reviews

Hayden's Hideout

Hayden's Hideout apartment is just two blocks from the Mississippi River and within walking distance of everything you need in downtown Guttenberg. Completely overhauled in the fall of 2020 with central air, furnace and fiber internet from Alpine Communications. Fully furnished private bathroom and kitchen. Adults only, no pets and no smoking. Conveniently located 150 feet from the Guttenberg Brewing Company where the food trucks are back for the 2023 season!

Jun 3 – 10

R1,213 ZAR per night