Waterfront vacation rentals in Cape Girardeau County

The exterior of a charming brick farmhouse is displayed, featuring a symmetrical layout with two dormer windows. A well-maintained lawn surrounds the house, complemented by flower beds. A walkway leads to the welcoming entryway, which opens to a sunroom on the right.

4.96 out of 5 average rating, 142 reviews

River Run

BobRating, 5 stars4 weeks ago

Laura was an exceptional host! Her attention to detail was amazing—everything in the space was thoughtfully prepared and beautifully maintained. The place was spotless, well-stocked, and incredibly comfortable. She clearly goes above and beyond to make guests feel welcome. Highly recommend staying here!

Apartment in Old Appleton

A red steel bridge spans over a serene creek, with water cascading down a rocky ledge in the foreground. Lush greenery surrounds the area, enhancing the peaceful ambiance of the scene. The sky is partly cloudy, adding to the tranquil atmosphere.

5 out of 5 average rating, 32 reviews

Apple Creek Loft

JeremyRating, 5 stars1 month ago

This place was way more than enough space for three of us, in fact at the price point it’s a great deal for the size. There is a beautiful waterfall right by the entryway, I kept my bedroom window open all night so I could hear it. Everything was really clean and we were able to use the kitchen to cook breakfast. I would definitely stay here again. They have some older TVs that are CRT based, so if you have an old NES with Duck Hunt bring it!!! Duck Hunt won’t work on new HDTVs. We were on motorcycles so we parked out front. The back parking lot is gravel and there’s a little bit of a rough entryway if you’re on bikes. Laundry room is big and works great. I wish we had more time to spend around the area. It was nice and quiet and very clean.

A private balcony offers outdoor seating with several chairs and a table. A clear view of the Mighty Mississippi River can be seen in the background, adding a scenic backdrop to the space. The balcony features a neutral-colored floor and walls.

4.83 out of 5 average rating, 35 reviews

The Outlook - Private Balcony

AndrayaRating, 5 stars1 month ago

This is the second time we have stayed at this place and it is the best place in town. We slept very well during the evening and enjoyed the amazing views during the day. Location is ideal and the parking garage guaranteed downtown parking in cape. Definitely recommend.

5 out of 5 average rating, 23 reviews

An open-concept living space is depicted with a mix of art pieces adorning the walls. Comfortable seating, including a sofa and armchair, is arranged around a wooden coffee table. Natural light filters in through a window, highlighting the warmth of the wooden flooring.

Loft in Cape Girardeau

Lorimier Loft Gallery next to SEMO River Campus

Directly across from Southeast Missouri State University’s River Campus, Lorimier Loft Gallery features luxury accommodations, purchasable gallery artwork and easy access to historic downtown Cape Girardeau. Every inch of this space delivers an aesthetic experience from the artwork to the tile-work to the location: Cross the street for performing art at the River Campus. Sit on the porch and listen to the marching band practice. Curl up by the fire and soak in a rich gallery during your stay.

A scenic view of the Mississippi River from a hillside, framed by lush green trees and foliage. The river is visible in the foreground, with a hint of a barge and distant hills creating a peaceful natural landscape.

Tiny home in Jackson

5 out of 5 average rating, 3 reviews

River View-Hines Landing Studio Cabin (Off-grid)

Overlooking the Mississippi River is a studio cabin on 200 acres of private property. The solar powered cabin has a back-up generator, indoor bathroom with shower and a gas stovetop (no oven). Excellent cell phone service, no Wifi/Internet-can use personal hotspot for Roku TV. Connect with nature outdoors as the cottage is not air conditioned. Unwind at this peaceful farm stay and experience green pastures, river views, beautiful sunrise/sunsets, bird watching, eagle and wildlife sightings.

Treehouse in Cape Girardeau

The custom-built treehouse is elevated on stilts, surrounded by greenery. A spacious deck features a railing, offering access to the entrance. Steps lead to the ground below, while large glass doors enhance the connection to nature.

4.99 out of 5 average rating, 142 reviews

Twisted Sassafras Treehouse

A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!

Vacation rentals for every style

Get the amount of space that is right for you

Apartments

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Unique stays

Spaces that are more than just a place to sleep

Popular amenities for Cape Girardeau County waterfront rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Waterfront apartment rentals

4.95 out of 5 average rating, 44 reviews

A serene view of the Mississippi River is presented, highlighting the tranquil water and the pavilion that juts into the river. Lush green grass borders the water, and trees line the distant shore, creating a natural landscape under a clear sky.

Apartment in Scott City

RiverSide Barn Suite on the Mississippi River.

ChrisRating, 5 stars1 day ago

Loved it! The view is gorgeous! Perfect Airbnb!

A private deck is highlighted, featuring a round glass table surrounded by six black metal chairs. The scenic view includes the Mississippi River and a colorful sunset, with the silhouette of the Emerson bridge visible in the background.

4.96 out of 5 average rating, 45 reviews

Downtown Condo on the River

RogerRating, 5 stars4 days ago

Place was very nice very clean. Definitely say there again.

Apartment in Old Appleton

5 out of 5 average rating, 32 reviews

Apple Creek Loft

JeremyRating, 5 stars1 month ago

This place was way more than enough space for three of us, in fact at the price point it’s a great deal for the size. There is a beautiful waterfall right by the entryway, I kept my bedroom window open all night so I could hear it. Everything was really clean and we were able to use the kitchen to cook breakfast. I would definitely stay here again. They have some older TVs that are CRT based, so if you have an old NES with Duck Hunt bring it!!! Duck Hunt won’t work on new HDTVs. We were on motorcycles so we parked out front. The back parking lot is gravel and there’s a little bit of a rough entryway if you’re on bikes. Laundry room is big and works great. I wish we had more time to spend around the area. It was nice and quiet and very clean.

4.83 out of 5 average rating, 35 reviews

The Outlook - Private Balcony

AndrayaRating, 5 stars1 month ago

This is the second time we have stayed at this place and it is the best place in town. We slept very well during the evening and enjoyed the amazing views during the day. Location is ideal and the parking garage guaranteed downtown parking in cape. Definitely recommend.

A modern living area features a sectional sofa and a recliner, providing comfortable seating. Light fixtures illuminate the space, and a ceiling fan enhances air circulation. A partition separates the entertainment area, which includes two televisions and decorative elements, contributing to a cozy atmosphere.

4.95 out of 5 average rating, 142 reviews

Private Downtown Apartment

AnastasiaRating, 5 stars1 day ago

Absolutely love staying at Kara’s place. Looks exactly like the pictures. She responded back fast whenever I would message her. Would definitely stay again.

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Waterfront house rentals

4.96 out of 5 average rating, 142 reviews

River Run

BobRating, 5 stars4 weeks ago

Laura was an exceptional host! Her attention to detail was amazing—everything in the space was thoughtfully prepared and beautifully maintained. The place was spotless, well-stocked, and incredibly comfortable. She clearly goes above and beyond to make guests feel welcome. Highly recommend staying here!

The exterior of Rivercrest Castle is displayed, showcasing a historic three-story structure painted in a warm yellow tone. A well-maintained yard features grass and a pathway leading to the entrance. Views of the Mississippi River are visible in the background, contributing to the property's appeal.

4.62 out of 5 average rating, 21 reviews

Rivercrest Castle

CalebRating, 5 stars1 week ago

Place was great for my friends and I to come and relax for a short weekend trip, loved the view of the river and felt cozy at home! Great place to stay and very spacious!

A stylish living area features a geometric black and white floor. A gray couch is paired with a bright red chair, while a modern chandelier hangs above. A television is mounted on the wall, and large windows provide a view of the outdoors.

4.87 out of 5 average rating, 47 reviews

Ace Of Hearts- 1 Bed 1 Bath

DatRating, 5 stars1 month ago

Everything was as described. I would stay here again

Superhost

A modern living area is presented, featuring a light grey sofa adorned with dark and light cushions. A wooden coffee table sits on a patterned area rug. Artwork and decorative items are arranged on the dark wall, with indoor plants adding a touch of greenery.