Guesthouse vacation rentals in Anderson County

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Top-rated guesthouse rentals in Anderson County

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Top guest favorite

A staircase with dark risers and light-colored steps leads to the upper level. The entryway is adorned with earthy tones, complemented by a circular mirror on the wall. Golf clubs are stored neatly in a corner, adding a touch of recreational charm.

Guesthouse in Abbeville

4.97 out of 5 average rating, 337 reviews

Scenic Loft in the Woods

Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!

Guest favorite

Guesthouse in Six Mile

4.96 out of 5 average rating, 154 reviews

Your Charming Country Cottage

Whether you need a country getaway or a place to lay your head after a football game, our cottage in the foothills of upstate SC is the perfect spot for both. You’ll find us tucked away just outside the quaint little town of Six Mile, 10 miles north of Clemson University and in close proximity to 3 of the upstate's favorite lakes: Lake Keowee, Lake Jocassee and Lake Hartwell. Here you’ll enjoy the serenity of country life without feeling “too far out" or away from all the upstate has to offer.

Top guest favorite

Guesthouse in Seneca

5 out of 5 average rating, 20 reviews

Hartwell Hideway

Escape to this cozy 1-bedroom, 1-bath apartment perched above a private garage on Lake Hartwell. It's just 15 minutes from Clemson University and quaint downtown Seneca. With a full kitchen, cozy living space, on-site parking, keyless entry, and owners nearby, you’ll have everything you need for a relaxing visit. ✔ New build 2024 ✔ Boat access 5 minutes away ✔ Hiking & waterfalls nearby Whether you're here for a Clemson game, a lake adventure, or a quiet getaway, this is the perfect home base.

Guest favorite

A view from the large attached deck showcases a well-maintained yard bordered by trees. A nearby brick house is visible, with a gravel driveway leading to it. The surrounding area exhibits a peaceful, wooded setting at sunset.

Guesthouse in Anderson

4.94 out of 5 average rating, 190 reviews

Private-Lake getaway-7 mile view from dock

Spacious two story guest house on a private road situated on Lake Hartwell. Use the double deck dock with 7 mile view for all day fishing, swimming or just relaxing. The guest house with central heating and air is fully furnished and has a fully equipped kitchen, wifi, 3 streaming flat screen tvs, two full baths, washer/dryer combo and a large attached deck. Owners live on property but in different residence. Outdoor cameras overlook parking area. Only reserved guests have property access.

Superhost

A spacious yellow barn-style structure with a green roof is visible, featuring three symmetrical gabled dormers. The ground level includes three garage doors, framed by lush greenery and a wooden fence, with a serene backdrop of trees.

Guesthouse in Anderson

4.86 out of 5 average rating, 194 reviews

Farmhouse by the lake - Private guest house

1,200 square foot apartment over a quiet barn on a cul-de-sac of a lake community. Near I-85, T. Ed Garrison Livestock Arena, downtown Pendleton, Clemson, and Lake Hartwell. Perfect for Clemson football games, horse/livestock shows or trail riding at Garrison Arena, lay over with horse, graduation, visiting your college student, fishing tournaments, or vacationing near Lake Hartwell. A private guest house overlooking sheep pastures and woods. Accessed by flight of stairs.

Guest favorite

Guesthouse in Anderson

4.94 out of 5 average rating, 16 reviews

Forested Retreat-Scenic Above Garage Suite

Welcome to our quiet mother-in-law suite located in the charming town of Anderson, South Carolina! Our cozy 1 bed 1 bath newly renovated above-garage apartment is the perfect spot for a peaceful and relaxing stay. Located in a quiet setting in the woods, you'll feel at one with nature while still enjoying all the modern amenities you need for a comfortable stay within 30 minutes to Greenville and Clemson and 10 minutes to Anderson University.

Top guest favorite

A well-lit pool is shown at night, featuring an inviting turquoise glow. Lounge chairs and a dining set are positioned nearby on a surface covered with outdoor decor. Soft light is visible emanating from the house in the background, providing a sense of warmth.

Guesthouse in Donalds

4.99 out of 5 average rating, 374 reviews

Home on the farm

aprox. 4 miles to Erskine College and aprox. 15 miles to Greenwood sc. You’ll love the farm setting, good for couples, solo adventurers, business travelers, families (with kids), and furry friends (pets).we are aprox. 11 miles from Abbeville SC birth place of the confederacy. aprox. 60 miles to Augusta GA the masters golf tour. aprox. 40 miles to CLEMSON U. The Diamond Hill Mine in Abbeville is about 17 miles from here.

Top guest favorite

Guesthouse in Liberty

4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

Holly Hideaway is nestled between Greenville and Clemson, in the small town of Liberty. It's perfect for business travelers, couples, Clemson parents, alumni, and small families. Tiled throughout for cleanliness. Privacy, tranquility, and clean, comfortable accommodations are what we provide. We are 10 minutes from Clemson and 3 miles from SWU. The Hideaway now offers Wi-Fi and Smart TV.

Top guest favorite

Guesthouse in Greenville

5 out of 5 average rating, 122 reviews

Sally's Cottage

Couples retreat located 6 miles from downtown Greenville and the Swamp Rabbit Trail in a comfortable country setting. Wake up to a beautiful woods view through a large bay window and wildlife that surrounds the cottage (deer, birds and squirrels). Experience the beauty of the country in the city! Enjoy the eclectic collection of art and design in this cute little cottage.

Top guest favorite

An aerial view reveals a spacious apartment nestled among dense trees near the edge of Lake Hartwell. A sandy shoreline curves along the water, with a driveway leading to the property, blending seamlessly into the tranquil, wooded surroundings.

Guesthouse in Hartwell

4.98 out of 5 average rating, 101 reviews

1 bedroom lake front apartment with gorgeous views

Relax in a cozy apartment on Lake Hartwell. The apartment is located in a secluded peaceful, cove near downtown Hartwell and is in close proximity to hiking and numerous outdoor activities in the hill country of Georgia and South Carolina. The apartment sleeps 2 comfortably and is fully equipped with a kitchen and a private laundry facility.

Guest favorite

A travel trailer is parked on a gravel area surrounded by trees. The exterior features light colors with dark accents, while a picnic table is positioned nearby on a partially rocky ground.

Guesthouse in Six Mile

4.9 out of 5 average rating, 126 reviews

Camper at Hickory Lodge and Guesthouse

Simple, relaxed atmosphere on a nicely wooded property less than 10 minutes from public launch and Sunset Marina on Lake Keowee. Boat parking is available. Only 19 minutes from Memorial Stadium, 15 minutes from Seneca, Pickens, Clemson. LESS THAN A MILE FROM DUKE OCONEE PLANT Need another bedroom? Please see our other listings

Top guest favorite

Guesthouse in Clemson

4.99 out of 5 average rating, 240 reviews

Clemson Cabana

Come & enjoy your own personal oasis. You'll have full private access to the salt water pool, mineral spa hot tub, outdoor ping pong table, and the gas grill. The cabana is designed for some major Rest & Relaxation. We are conveniently located less than a mile from local restaurants and grocery stores.