
Vacation rentals in Santee River
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Top-rated vacation rentals in Santee River
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Popular amenities for Santee River vacation rentals
Other great vacation rentals in Santee River
Top guest favorite

Guesthouse in Summerville
5 out of 5 average rating, 53 reviews2 King beds 2 Bath*Fire Pit* Downtown Summerville
Guest favorite

Home in Manning
5 out of 5 average rating, 25 reviewsWyboo Retreat at Lake Marion W/Pool

Home in Ladson
New place to stayModern Home w/ Theater, BBQ & Private Yard
Guest favorite

Guesthouse in Summerville
5 out of 5 average rating, 5 reviewsElledot Cottage 1 king bed, 1 set bunk beds
Guest favorite

Apartment in Johns Island
5 out of 5 average rating, 7 reviewsHomey private studio w/ kitchenette
Top guest favorite

Treehouse in Adams Run
5 out of 5 average rating, 47 reviewsTree House Close to Beach
Guest favorite

Home in Manning
4.88 out of 5 average rating, 57 reviewsCozy Church Branch Cabin
Guest favorite

Home in Bonneau
4.93 out of 5 average rating, 74 reviewsLakefront Retreat w/ Game Room & Private Dock!
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- Park Circle
- Love's a Beach
- Huntington Beach State Park
- Sullivan's Island Beach
- Bulls Island
- Garden City Beach
- Middleton Place
- James Island County Park
- Waterfront Park
- The Golf Club at Wescott Plantation
- Caledonia Golf & Fish Club
- Shem Creek Park
- Angel Oak Tree
- Hampton Park
- The Charleston Museum
- Morris Island Lighthouse
- Isle of Palms Beach
- Charleston Aqua Park
- Gibbes Museum of Art
- White Point Garden
- Whirlin' Waters Adventure Waterpark
- Litchfield Beach and Golf Resort
- Broken Groin
- Tupelo Bay Golf Center