Vacation rentals in De Soto

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in De Soto

Guests agree: these stays are highly rated for location, cleanliness, and more.

Guest favorite

Home in Carbondale

5.0 out of 5 average rating, 503 reviews

Charming 3 bedroom bungalow in Downtown Carbondale

Originally built in 1920, this cute bungalow house has been totally renovated and modernized. You'll enjoy 3 furnished bedrooms, 1 bathroom, covered porch, and back with lighted pergola and firepit. The location is exceptional - just two blocks North of the Carbondale downtown "strip," and EASILY walkable to all the downtown businesses, Memorial Hospital of Carbondale (0.4 miles), restaurants, pubs, Amtrak station (0.5 miles), and SIU (about 1.2 miles). Officially Permitted Airbnb VRU 23-03

Mar 6 – 13

R2,047 ZAR per night
Guest favorite

Home in Murphysboro

4.89 out of 5 average rating, 83 reviews

Home Away From Home

Enjoy our cozy 2 bedroom home, the sofa bed lets larger families enjoy their stay too. For 6 adults it may be a bit tight but we have had 7 guests in the past. A well equipped kitchen has the laundry. Fully stocked fridge for breakfast. There’s a covered patio and carport. House is in a quiet residential area only a short drive to restaurants, antique & specialty shops. Beautiful hiking trails, lakes, orchards, SIU Campus, ShawneeWine Trail, Microbreweries & many other sights await your visit.

Sep 3 – 10

R1,853 ZAR per night
Guest favorite

Guesthouse in Carbondale

5.0 out of 5 average rating, 171 reviews

Homestead Cottage

Enjoy tiny farmhouse life in this adorable 375 sq. foot cottage. Loaded with everything you need this little cottage is nestled privately behind some trees on our 11 acre farm. You will soon forget how close you are to town with the beautiful view from your windows and the pasture fence just steps out the back door. Whether you’re here for the wineries, amazing hiking, an SIU event (3 miles) or to visit with family, the Homestead Cottage will provide a comfortable retreat from any adventure.

Sep 9 – 16

R1,573 ZAR per night

Popular amenities for De Soto vacation rentals

Other great vacation rentals in De Soto

Guest favorite

Apartment in Murphysboro

4.94 out of 5 average rating, 17 reviews

The Windbreak

May 11 – 18

R1,395 ZAR per night
Guest favorite

Apartment in Du Quoin

4.88 out of 5 average rating, 16 reviews

The 'Hideaway'-Close to DuQuoin State Fairgrounds

Apr 19 – 26

R1,945 ZAR per night
Guest favorite

Apartment in Du Quoin

4.95 out of 5 average rating, 93 reviews

30 West..The Den (#2)

Dec 17 – 24

R1,662 ZAR per night
Guest favorite

Home in Herrin

4.96 out of 5 average rating, 23 reviews

Charming 3 bedroom retreat

Jan 9 – 16

R2,241 ZAR per night
Guest favorite

Home in Murphysboro

5.0 out of 5 average rating, 54 reviews

Embers of Murphysboro

Feb 18 – 25

R6,697 ZAR per night
Guest favorite

Home in Du Quoin

5.0 out of 5 average rating, 14 reviews

Du Quoin Fairgrounds/ Large parking lot

Apr 11 – 18

R2,940 ZAR per night
Guest favorite

Apartment in Murphysboro

4.96 out of 5 average rating, 26 reviews

2br Private Guest Suite In Town on 4 Acre Estate

Aug 9 – 16

R2,092 ZAR per night
Guest favorite

Home in Carterville

4.97 out of 5 average rating, 32 reviews

Welcoming, Pet-Friendly Home in Carterville

Feb 24 – Mar 3

R2,183 ZAR per night
Guest favorite

Home in Du Quoin

5.0 out of 5 average rating, 22 reviews

Clean and cozy, Centrally Located in DuQuoin

Sep 3 – 10

R2,512 ZAR per night
Guest favorite

Home in Murphysboro

4.98 out of 5 average rating, 51 reviews

Mary and Snooks' Cozy Country Farm House.

Jul 21 – 28

R2,921 ZAR per night
Guest favorite

Home in Carterville

4.82 out of 5 average rating, 28 reviews

Cottage on Grand

Aug 8 – 15

R2,409 ZAR per night
Guest favorite

Home in Ava

4.82 out of 5 average rating, 55 reviews

Sunset View Lodging

Mar 9 – 16

R2,219 ZAR per night

Destinations to explore

  1. Airbnb
  2. United States
  3. Illinois
  4. Jackson County
  5. De Soto