Cape Girardeau vacation rentals

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Apartment in Cape Girardeau

4.97 out of 5 average rating, 351 reviews

Beautiful Historic Boulevard District Apartment

This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.

Aug 4 – 11

R1,976 ZAR per night

Guest favorite

Home in Jackson

4.92 out of 5 average rating, 266 reviews

The Rusty Owl-A Charming Victorian Dwelling

The Rusty Owl is a peaceful place with easy access to I-55. House has high speed (300 up and down) wifi. Jackson: Check out Flickerwood Arena, (9 minutes away... for ATV and barrel racing; horse shows and rodeos) Jackson History Center: Free. Open daily. Cape Girardeau: Live music and relaxation at The Library and 21 Taps. Hunter Valley Winery open weekends. 1 private lower level queen bedroom/ two private (1 queen, 1 twin) rooms and room with a antique full bed and a twin bed upstairs.

Jul 21 – 28

R2,274 ZAR per night

Guest favorite

Guest suite in Cape Girardeau

4.96 out of 5 average rating, 111 reviews

MAINSTAY CAPE [downtown]

Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.

Oct 2 – 9

R1,516 ZAR per night

Guest favorite

Apartment in Cape Girardeau

4.94 out of 5 average rating, 172 reviews

Brand new 2 bedroom unit right in downtown Cape.

This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .

Mar 15 – 22

R2,370 ZAR per night

Guest favorite

Home in Cape Girardeau

4.97 out of 5 average rating, 117 reviews

River Run

Charming 1940s farmhouse. Updated 1 1/2 story house in a rural setting overlooking the Mighty Mississippi River, but close to the heart of Cape Girardeau. Our house has lots of room to relax with a large kitchen and sunroom. You can sit by a cozy fire pit and enjoy chilly evenings watching the beautiful sunsets. We look forward to you spending time in our neck of the woods (so to speak). We are located with in seven miles from the Isle casino, SEMO state university and a happening down town.

Aug 14 – 21

R4,584 ZAR per night

Guest favorite

Apartment in Cape Girardeau

4.85 out of 5 average rating, 532 reviews

Unique Design | Walk Downtown/River | .5 mile SEMO

At our Adventurous 2 Bedroom Suite you’ll first arrive at a Brightly decorated Space with Artsy Walls and Bold Decor. Designed with its History in mind & a twist of Creativity, you will Immerse Yourself within your Stay; from our Stocked Kitchen, Reading Area with Indoor Swing to Themed & Cozy Bedrooms. Enjoy being near Downtown/the River with a short Bike Ride or Walk and when you are ready to Tuck in at night, Sink into our 10” Memory Foam mattress with Plush Pillows and feel at Ease.

Mar 22 – 29

R1,764 ZAR per night

Guest favorite

Barn in Cape Girardeau

4.95 out of 5 average rating, 107 reviews

Under the Stars - Farmhouse

Enjoy the tranquility of this modern farmhouse charmer! Custom built only 2 years ago. Minutes from downtown Cape. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Relax in the front porch rocking chairs, hang out in the vaulted ceiling family area or game loft! Enjoy the sounds of nature around the fire pit, roasting marshmallows and watching the sunset. Near Trail of Tears and walking distance to classic dive bar/burger joint.

Sep 23 – 30

R4,065 ZAR per night

Guest favorite

Home in Cape Girardeau

4.92 out of 5 average rating, 161 reviews

College town Charm: Minutes from Downtown Cape

EXCELLENT LOCATION near downtown riverfront Cape! Enjoy live music, local dining/coffee, shopping, casino, and seasonal steamboat rides downtown. Less than 5 min. from Southeast Missouri State University & Southeast Hospital. Centrally located near wedding venues: Rusted Route, Deerfield, Watersedge, Sweet Pecan, and Country Club. 2 blocks from scenic Capaha Park. Home to Capaha baseball. This huge park includes play structures, basketball court, disc golf & fishing pond.

May 24 – 31

R2,058 ZAR per night

Guest favorite

Place to stay in Cobden

4.95 out of 5 average rating, 272 reviews

Eva's Roost Retreat - Center For Lost Arts

Eva's Roost -a uniquely crafted rustic, zen-style cottage, designed to be close to the earth & nature. Expensive curtainless windows facing the forest & pond allow for private views: sunrise, moonrise, forest & wildlife. Personal outdoor space with firepit & comfy adirondack chairs. Paul is the architect & designer of Center For Lost Arts structures, furniture & grounds. Bonnie is a mindfulness meditation teacher who enjoys creating a welcoming space for all to enjoy year-round.

May 29 – Jun 5

R2,148 ZAR per night

Guest favorite

Cottage in Cape Girardeau

4.98 out of 5 average rating, 178 reviews

Historic Cottage Walkable to Downtown Cape

This welcoming 3 bedroom, 2.5 bathroom brick German vernacular cottage on a tree-lined street is just 2 blocks away from the Mighty Mississippi River and historic downtown Cape Girardeau's shops, restaurants, historic sites, river walk, and SEMO's River Campus. This home has been restored with an eye for family gatherings and was built by Joseph Lansman in 1892. We were honored to receive the Judith Ann Crow Residential Historic Rehabilitation Award from Old Town Cape in 2021!

May 21 – 28

R3,057 ZAR per night

Guest favorite

Loft in Cape Girardeau

4.9 out of 5 average rating, 187 reviews

Riverwalk Loft 3

Historical building with modern amenities. We are located right in the middle of downtown life. With the excitement there will come noise from bars, live bands, and the occasional train. If you love staying where fun is happening, this ones for you. Please note: we are located above an arcade bar and you are a building up from the River wall. There is also a currently operational TRAIN track with TRAINS, that make TRAIN noises 200ft from our lofts.

Mar 8 – 15

R2,574 ZAR per night

Guest favorite

Cabin in Cape Girardeau

4.93 out of 5 average rating, 180 reviews

Log Cabin w/ Hot tub - Near Casino & Downtown Cape

THE BEST GETAWAY HERE IN CAPE! Have a relaxing staycation here in Cape Girardeau Perfect for a QUICK GETAWAY for couples, families or friends 5 MINS to the casino, country club and downtown cape Very unique log home with a private bedroom queen size bed, pull-out queen size bed in the living room and double futon SLEEPS 6. Pool table, darts, and a hot tub.There is a large deck and fire pit which has the feel of being in the woods.

Mar 6 – 13

R2,558 ZAR per night

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Cape Girardeau vacation rentals

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Air conditioning

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend

Dogwood Social House3 locals recommend

Port Cape13 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favorite

Treehouse in Perryville

5.0 out of 5 average rating, 510 reviews

TreeLoft at BaseCamp

Nov 24 – Dec 1

R6,114 ZAR per night

Superhost

Cabin in Bloomsdale

4.86 out of 5 average rating, 243 reviews

Getaway St. Francois - St. Louis

Jul 4 – 11

R2,898 ZAR per night

Guest favorite

Treehouse in Makanda

4.98 out of 5 average rating, 177 reviews

Panthers Inn Treehouse

Jan 31 – Feb 7

R2,997 ZAR per night

Guest favorite

Treehouse in Greenville

5.0 out of 5 average rating, 143 reviews

NEW treehouse B&B for 2 "The Roost” with hot tub

Nov 13 – 20

R3,345 ZAR per night

Guest favorite

Cabin in Williamsville

4.99 out of 5 average rating, 218 reviews

Secluded Cabin on BlackRiver/ Hot tub- NO PETS!

Sep 26 – Oct 3

R3,579 ZAR per night

Guest favorite

Farm stay in Fredericktown

4.93 out of 5 average rating, 285 reviews

NEW DC Farmhouse Come relax in our HOT JACUZZI

Aug 29 – Sep 5

R2,348 ZAR per night

Guest favorite

Cabin in Alto Pass

4.99 out of 5 average rating, 212 reviews

Ma's Cabin, Alto Pass, IL. Fine country lodging.

Feb 24 – Mar 3

R1,586 ZAR per night

Guest favorite

Treehouse in Cape Girardeau

4.98 out of 5 average rating, 58 reviews

Twisted Sassafras Treehouse

Dec 4 – 11

R4,685 ZAR per night

Show all

Other great vacation rentals in Cape Girardeau

Guest favorite

Guesthouse in Cape Girardeau

4.9 out of 5 average rating, 61 reviews

Cozy 1-BR guest house w/free parking on premises

Jan 23 – 30

R1,542 ZAR per night

Guest favorite

Home in Cape Girardeau

4.93 out of 5 average rating, 40 reviews

Cozy Cottage

Nov 1 – 8

R2,543 ZAR per night

Guest favorite

Home in Cape Girardeau

4.83 out of 5 average rating, 65 reviews

3 Bed Adorable Home: Next to Hospital + SEMO

Feb 3 – 10

R2,382 ZAR per night

Guest favorite

Guest suite in Cape Girardeau

5.0 out of 5 average rating, 93 reviews

Cape Comfy! Close to SEMO & Capaha! CLEAN! 5 Star!

Jun 8 – 15

R1,378 ZAR per night

Guest favorite

Apartment in Cape Girardeau

4.95 out of 5 average rating, 20 reviews

Downtown Condo on the River

Apr 30 – May 7

R2,616 ZAR per night

Guest favorite

Guest suite in Cape Girardeau

4.85 out of 5 average rating, 60 reviews

[*Charming Cozy Suite*]

Feb 8 – 15

R1,038 ZAR per night

Guest favorite

Apartment in Cape Girardeau

4.8 out of 5 average rating, 25 reviews

Gail's Corner Window- River View

Jun 19 – 26

R2,789 ZAR per night

Superhost

Home in Cape Girardeau

4.79 out of 5 average rating, 28 reviews

3 Bed Bungalow w/ Deck and Fenced-In Back Yard

Feb 4 – 11

R1,963 ZAR per night

Show all

Quick stats about vacation rentals in Cape Girardeau

Total rentals
150 properties
Rentals with dedicated workspaces
90 properties have a dedicated workspace
Pet-friendly rentals
40 properties allow pets
Family-friendly rentals
80 properties are a good fit for families
Total number of reviews
8.1K reviews
Nightly prices starting at
R383 ZAR before taxes and fees

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Cape Girardeau?
Yes! Work meets play with ease at over 90 vacation rentals in Cape Girardeau featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there pet-friendly vacation rentals in Cape Girardeau?
Four-legged friends are welcome in Cape Girardeau. Choose from more than 40 vacation rentals for guests traveling with pets.
Do apartment rentals in Cape Girardeau have wifi?
Absolutely! We offer over 40 apartment rentals with wifi in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
How much does it cost to stay in apartment rentals in Cape Girardeau?
Experience the best of Cape Girardeau with our apartment rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there family-friendly apartment rentals in Cape Girardeau?
Cape Girardeau has more than 20 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
Do house rentals in Cape Girardeau have a bbq area?
Absolutely! We offer over 10 house rentals with a bbq area in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
Do apartment rentals in Cape Girardeau have air conditioning?
Absolutely! We offer over 30 apartment rentals with air conditioning in Cape Girardeau. Enjoy a tailored experience with all the comforts you desire.
What are the most popular amenities for Apartment Rentals in Cape Girardeau?
Enhance your stay in our Apartment Rentals with the most popular amenities: over 30 homes with air conditioning, over 40 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

Cape Girardeau vacation rentals

Top-rated vacation rentals in Cape Girardeau

Vacation rentals for every style

Cabins

Apartments

Hotels

Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Other great vacation rentals in Cape Girardeau

Treehouse in Perryville

Cabin in Bloomsdale

Treehouse in Makanda

Treehouse in Greenville

Cabin in Williamsville

Farm stay in Fredericktown

Cabin in Alto Pass

Treehouse in Cape Girardeau

Other great vacation rentals in Cape Girardeau

Guesthouse in Cape Girardeau

Home in Cape Girardeau

Home in Cape Girardeau

Guest suite in Cape Girardeau

Apartment in Cape Girardeau

Guest suite in Cape Girardeau

Apartment in Cape Girardeau

Home in Cape Girardeau

Quick stats about vacation rentals in Cape Girardeau

Total rentals

Rentals with dedicated workspaces

Pet-friendly rentals

Family-friendly rentals

Total number of reviews

Nightly prices starting at

Frequently Asked Questions

Are there vacation rentals with a dedicated workspace in Cape Girardeau?

Are there pet-friendly vacation rentals in Cape Girardeau?

Do apartment rentals in Cape Girardeau have wifi?

How much does it cost to stay in apartment rentals in Cape Girardeau?

Are there family-friendly apartment rentals in Cape Girardeau?

Do house rentals in Cape Girardeau have a bbq area?

Do apartment rentals in Cape Girardeau have air conditioning?

What are the most popular amenities for Apartment Rentals in Cape Girardeau?

Destinations to explore