Panacea vacation rentals

A wooden boardwalk leads to the beach, framed by two benches on either side. The ocean is visible in the distance under a clear blue sky, with sunlight shining directly overhead.

5 out of 5 average rating, 10 reviews

La Mer - Beachfront Condo, Saint George Island, FL

Enjoy our 5 Star Island Lifestyle Beachfront Condominium. New curated comfort décor with stunning views of our award-winning Gulf beaches. Centrally located, the Villas of St. George is close to shops, restaurants, nightlife, Lighthouse Museum and playground, fishing pier, State Park, and food trucks. With Private Community pool, parking & boardwalk direct to sugar sand shores. Sleeps 8: Pull out sleeper sofa(King), 1 King, 2 full, 1 twin(trundle). Sorry Pets are not allowed at this property.

4.86 out of 5 average rating, 211 reviews

Tiny home in Carrabelle

The Sweet Peach - 2 Adults 1 toddler

This NOT so tiny, tiny home is located across from the bay, has everything needed to enjoy your vacation. Completely remodeled in 2017. Shabby chic, beach decor, Q sized bed, 2 stuffed chairs & complete kitchen. Screened in porch, dining area, chairs. Relax with a beverage & enjoy the amazing view of the bay. Affordable small family (2 adults 1 small child) vacation or romantic getaway. Professionally cleaned after each guest stay. Bathroom is small with corner shower. Pet policy in listing

Townhouse in Apalachicola

A spacious balcony features four wooden adirondack chairs positioned for river views, with a small table between them. An American flag is displayed, fluttering in the breeze. The horizon showcases the water, complemented by a sunny sky with scattered clouds.

5 out of 5 average rating, 147 reviews

Apalachicola Getaway on Water Street

Corner townhouse in the High Cotton Marketplace. Watch shrimp boats pass from the spacious balcony. Browse shops & sip coffee - all within our building! Sony OLED tv's, Stearns & Foster king beds, king sleeper sofa & a fully appointed gourmet kitchen. Free bikes, beach towels, umbrellas & chairs. Near a live music venue, so consider before booking. Max occupancy is 6 + infant. Not suitable for toddlers. Prefer kids 12 & over. No pets. Service animals require pre-booking approval. Contact host.

4.9 out of 5 average rating, 104 reviews

A view from the covered porch captures a rainbow arching over the calm bay waters. The scene includes a grassy shoreline and a wooden dock extending into the water. Flower pots are arranged on the patio, enhancing the outdoor space.

Cottage in Eastpoint

Cool Change - Lot 2

Our waterfront cottages are just a short drive to some of the area's favorite restaurants, breweries & 7 minutes from Saint George Island. Throw a line from the dock, head out on your boat or hit the water in your kayak. They can accommodate up to 6 guest & feature a fully stocked kitchen, bathroom, queen bedroom, bunk beds, pull-out-couch, flat screen TV's & a back porch overlooking the bay. We are also located next door to a public boat ramp with parking, Sfd retail market bait-tackle-shop.

4.89 out of 5 average rating, 103 reviews

A covered gazebo features a circular concrete patio surrounded by six comfortable seating chairs. In the center, a stone fire pit offers a cozy gathering spot. Lush green grass and trees provide a natural backdrop, enhancing the outdoor relaxation experience.

Cottage in Crawfordville

Breezeway Cottage

This brand new build is fully fenced in with a fire-pit, grill, and screened-in patio. Egyptian cotton sheets, blankets, towels and cleaned to highest standard! Get away from it all and come experience true feel of Relaxation. The house is located close to all the beaches, state parks, restaurants, and springs. We specifically designed and built these for Airbnb travelers to enjoy their own privacy while exploring Wakulla county. House has 1 king bed, 2 queen beds, and full size day bed.

A large, furnished screened porch features a blend of seating areas, including a table with chairs and a casual lounge space. A neutral-toned rug complements the warm wooden flooring. Steps lead from the porch to the outdoor area, providing easy access.

5 out of 5 average rating, 5 reviews

Redfish: view, pool, steps2beach

Just over the dune line road from quiet east end beaches. Great fishing and uncrowded relaxing . Excellent for families or couples (4 person maximum) with private spaces indoor and out. Two master bedrooms with kings and pillow tops. Second floor cottage recently remodeled and decorated. Shared pool and gulf views from front room and master. Front Deck. Large furnished screened porch. You will be hard pressed to find a better spot for your vacation dollars. Beach wagon, umbrella and chairs.

4.92 out of 5 average rating, 160 reviews

A single-story home features a welcoming front porch with green railings and a decorative entrance. A light color palette of the exterior is complemented by green shutters, and tall palm plants line the front yard, creating an inviting outdoor space surrounded by natural landscaping.

Home in Panacea

Fishermans Retreat

Fisherman's Retreat is the perfect location to get away from the stress of the city. Located in the heart of the quiet and cozy Panacea ocean community you are close to several beaches, boat ramps, favorite local fishing spots, kids playground across the street and our outstanding Gulf Specimen Aquarium that is fun for all ages. Plus, you can take in and enjoy several local restaurant that will satisfy every culinary appetite. So, check out of the big city and check into our relaxing home.

Bungalow in Alligator Point

4.93 out of 5 average rating, 140 reviews

"Finest Kind" - Direct Oceanfront & Bay Access

Newly renovated beachfront bungalow with a captivating direct unobstructed (100 foot) oceanfront view. (note, directly in front of house is a rock wall - not beach.) Crowd-free public beach nearby & private bay right outside your door. Great location for star-gazing at night & beautiful ocean view sunrises & sunsets. Perfect location for fishing, kayaking, boating, bicycling & other beachside activities. Catch shrimp from the gulf & hook up in the bay only footsteps away. Outdoor Shower

4.9 out of 5 average rating, 115 reviews

The exterior of the Riverwalk Cottages features a charming white bungalow with a bright teal door. A red metal roof contrasts with natural greenery surrounding the building. Small shrubs and gravel pathways are visible, creating a welcoming entrance.

Cottage in Carrabelle

The Oyster Bed- Riverwalk Cottages Unit 204 B

Welcome to the Oyster Bed at Riverwalk cottages in the heart of carrabelle. This is a small one bedroom bungalow that offers comfort and luxury! Comes with a well equipped kitchenette. You can walk across the street to the riverfront shops, bars and restaurants. We are PET FRIENDLY! Located Less than a mile to the carrabelle beach and just a quick 20 min ride to beautiful St George Island. Boat parking!!!! Come explore this quaint fishing village. Please look for the Oyster Bed sign

4.92 out of 5 average rating, 159 reviews

A welcoming sign announces Golden's Cottages Vacation Rentals. The sign combines teal and white colors, clearly stating the name and services offered. Below, a black section provides contact information and mentions cypress wood and live edge slabs.

Cottage in Eastpoint

River Cottage @ Golden's Cottages Vacation Rentals

The River Cottage at Golden's Cottage's Vacation Rentals is just a short 2 blocks to the Apalachicola Bay and boat launching areas known for great fishing. Open floor plan with 1 king Beds, Smart TV, Coffee bar, Microwave, Mini Fridge, Dinning for two, Private Bathroom, and Large Private Deck. Free Vehicle and Boat Parking on site. Shared Grilling Area with Picnic Tables and Fire Pit. One of three cottages on property, Great for Families. Come Have a "Golden" time on the Forgotten Coast.

4.9 out of 5 average rating, 116 reviews

A luxury travel trailer is highlighted under soft evening lights, nestled beneath a spacious covered porch. Two cozy outdoor chairs surround a fire pit, integrating relaxation and comfort within a serene outdoor setting.

Camper/RV in Carrabelle

Gone Coastal Luxury Glamper by the Beach

This coastal paradise is a luxury travel trailer located in the small town of Carrabelle, FL on the Forgotten Coast known for fishing, boating, golfing and relaxing. Whether you’re staying for the weekend or relaxing for a month-long getaway, this is the perfect place for you. With restraunts, live music, public boat ramps for fishing and boating to Dog Island and St. George Island, charter fishing, air boat rides, War Museums, lighthouse tours & beautiful white sandy beaches.

4.99 out of 5 average rating, 341 reviews

A well-lit bathroom features a modern sink with an attractive countertop, positioned beneath an illuminated mirror. The rustic-style barn doors add character, while an angled window brings in natural light. The flooring is designed with a wood-like texture, enhancing the space's warmth.

Home in Eastpoint

Point Break- Take a break at the Point

Nested 2 blocks from Apalachicola Bay, 10 minutes from the Apalachicola River and 10 minutes from St George island, our cozy cottage is a new build that has all of the comforts of home. Four adults can stay comfortably with 2 very comfortable beds and 1 bathroom. We also have a fold out cot perfect size for a child. Our home is in a very quiet neighborhood located on a cul-de-sac and is a short driving distance from fishing, hunting, shopping and sight- seeing adventures.

Vacation rentals for every style

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Popular amenities for Panacea vacation rentals

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Stay near Panacea's top sights

Gulf Specimen Marine Lab & Aquarium35 locals recommend

Posey's Up the Creek Steam Room22 locals recommend

The Seineyard Rock Landing17 locals recommend

Dollar General6 locals recommend

My-Way Seafood6 locals recommend

Mineral Springs Seafood By The Bay10 locals recommend

Panacea beach vacation rentals

The exterior of the beach home is showcased, featuring a light-colored facade with ample windows. The home is elevated on stilts, surrounded by landscaped grass and various plants. A set of steps leads up to the front entrance, with a clear blue sky in the background.

4.96 out of 5 average rating, 79 reviews

*Beach House w TIKI BAR*

An aerial view of a contemporary home with a teal roof, situated on pilings amid a coastal landscape. Nearby structures with varied colors contribute to the laid-back island atmosphere. The Gulf of Mexico is visible in the distance, framed by a clear blue sky.

4.82 out of 5 average rating, 234 reviews

100 STEPS TO THE GULF-CONTEMPORARY-SOARING CEILING

Bungalow in Alligator Point

A serene beach scene captures a vibrant sunset over the Gulf of Mexico. The warm hues of orange and yellow reflect on the water's surface, while gentle waves lap against the sandy shoreline, creating a tranquil atmosphere.

4.96 out of 5 average rating, 118 reviews

Unplugged

4.92 out of 5 average rating, 66 reviews

An aerial view of a light blue cottage nestled among tall pine trees. A gravel driveway leads to the front porch, surrounded by green shrubbery and landscaping. Nearby building roofs are visible through the tree canopy.

Home in Saint Teresa

Cozy coastal cottage w/pool and dogs are welcome!

Condo in Saint George Island

A sandy beach is filled with a variety of seashells, reflecting muted tones in the soft light of sunset. Gentle waves can be seen lapping at the shore, complementing the serene atmosphere created by the distant horizon.

4.9 out of 5 average rating, 132 reviews

Walk to Beach & Attractions! Remodeled & Spacious

Apartment in Saint George Island

An aerial view captures the property’s proximity to the beach, with sandy shores leading to the coastline. Surrounding homes are visible, showcasing a mix of colors and designs. The lush greenery in the background contrasts with the blue waters, emphasizing the tranquil setting.

4.72 out of 5 average rating, 68 reviews

BEACH BUM COTTAGES NEXT TO BEACH WITH POOL3

4.98 out of 5 average rating, 56 reviews

A two-story house is depicted with a light purple exterior and large screened porches on the upper level. The surrounding yard contains grass and small shrubs, with stepping stones leading towards the entrance.

Home in Eastpoint

CR Beach

4.93 out of 5 average rating, 88 reviews

A covered deck features a round table surrounded by four metal chairs, providing a comfortable space for outdoor dining. A serene view of lush greenery is visible in the background, with a wooden floor that enhances the inviting atmosphere.

Condo in Crawfordville

Shell Point Beach 2BR condo | Balcony views

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House rentals in Panacea

A welcoming front porch is featured, with two blue chairs positioned invitingly. Lush green landscaping surrounds the area, complemented by a neatly trimmed garden bed. The brick facade provides a sturdy backdrop, while sunlight filters gently through the trees, creating a serene outdoor atmosphere.

4.98 out of 5 average rating, 226 reviews

Centrally Located 2b/2b Tallahassee Retreat

A single-story home is presented with a covered front porch, featuring a black bench. The exterior is adorned with light grey siding and red brick accents, framed by a manicured lawn and surrounding trees. A pathway leads from the sidewalk to the porch entrance.

5 out of 5 average rating, 6 reviews

4 Sweet Suites near FSU.

A modern living area is presented with a gray sofa adorned with colorful cushions. A glass coffee table sits atop a patterned rug, enhancing the space. A warm yellow armchair adds a pop of color, while a floor lamp and a table lamp provide soft lighting.

4.91 out of 5 average rating, 108 reviews

Beautiful home with room for the entire family!

A modern living area features dark leather seating arranged around a silver coffee table. A ceiling fan provides airflow above, while a large TV mounted on the wall displays a scenic sunset. A dining area with grey barstools is visible in the background.

4.98 out of 5 average rating, 219 reviews

Intimate 3/3 by FSU, FAMU, & downtown Tallahassee

The living room features a white leather chesterfield sofa paired with wooden accent chairs and a glass coffee table. Natural light fills the room through a large window with horizontal blinds. Artwork is displayed on the walls, and a subtle rug adds warmth to the hardwood floor.

4.81 out of 5 average rating, 26 reviews

Luxury 2 kings private side home

A spacious outdoor area is shown, featuring a newly constructed home in the background. A wooden fence encloses the property, providing privacy. Ample parking space is available in front of the house, which is accented by a clear blue sky and lush trees in the vicinity.

4.76 out of 5 average rating, 17 reviews

Brand NEW House-.5Mi to FSU/1.6Mi to FAMU

A welcoming living area features two gray sofas adorned with green accent pillows, positioned around a round wooden coffee table. Natural light filters through sheer curtains, illuminating the hardwood floors. A potted plant adds a touch of greenery to the space.

4.82 out of 5 average rating, 204 reviews

3 Bedroom Trendy Elegant Vibe close to Colleges

An inviting living area features a spacious sectional sofa and a television mounted on the wall, displaying serene imagery. A sleek coffee table sits atop a patterned rug, and decorative plants are placed nearby, enhancing the welcoming ambiance of the space.

5 out of 5 average rating, 7 reviews

4 bdr/3 bth Townhome 5 mins FSU

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Beach house rentals in Panacea

5 out of 5 average rating, 24 reviews

A wooden deck is surrounded by lush greenery and tall trees, offering seating with a fire pit at its center. The tranquil freshwater canal is visible nearby, enhancing the peaceful setting. Clear blue skies stretch above, creating a serene outdoor ambiance.

Home in Panacea

Face in the Wind

4.95 out of 5 average rating, 19 reviews

The exterior of the beach house features a classic design with a metal roof and wide front steps leading to double wooden doors. Large windows framed by white siding provide natural light, while a landscaped area with blue and red foliage enhances the home’s entrance.

Home in Saint Teresa

Pure Bliss

A wooden deck overlooks a sandy beachfront, where gentle waves meet the shore. Tall trees offer shade, creating a tranquil setting. A clear blue sky stretches above, enhancing the serene environment by the water.

5 out of 5 average rating, 32 reviews

Tucked Away Private Beachfront Home

A three-story beach house is observed amid natural surroundings, featuring a light exterior and a metal roof. Large windows allow abundant light to filter in, while palm trees accentuate the entrance. A spacious driveway area is visible with gravel and greenery on either side.

4.72 out of 5 average rating, 100 reviews

Oceanview, Private beach in gated community

A coastal house features a light-colored exterior and a metal roof, elevated on stilts above the sandy ground. A set of stairs leads up to a spacious deck, while expansive windows offer views of the surrounding nature.

4.96 out of 5 average rating, 51 reviews

Reel Paradise beachfront House

4.95 out of 5 average rating, 66 reviews

Direct beachfront private luxury villa Sea La Vie

4.89 out of 5 average rating, 28 reviews

The image captures a tranquil swimming pool under a screened enclosure, reflecting the vibrant colors of a sunset. Lush potted plants are positioned near the pool, and wooden decking is visible, enhancing the serene outdoor ambiance.

Home in Eastpoint

Eastpoint on the Bay- Private Beach, Pool, Sunsets