
Vacation rentals in O'Brien
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Top-rated vacation rentals in O'Brien
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Popular amenities for O'Brien vacation rentals
Other great vacation rentals in O'Brien
Guest favorite

Home in Fort White
5 out of 5 average rating, 14 reviewsCozy 3 Bdrm Cottage Retreat by the Springs
Top guest favorite

Tiny home in Fort White
4.97 out of 5 average rating, 77 reviewsTiny Cabin close to the river and springs.
Top guest favorite

Home in Branford
5 out of 5 average rating, 23 reviewsThe Cottage at the Oasis near the Santa Fe River
Top guest favorite

Home in Live Oak
5 out of 5 average rating, 54 reviewsNature + Music + Town | Cozy Farmhouse Retreat
Superhost

Camper/RV in McAlpin
4.57 out of 5 average rating, 7 reviewsPeaceful vintage camper
Guest favorite

Home in Lake City
4.94 out of 5 average rating, 62 reviewsModern & Convenient 3/2 Home
Top guest favorite

Home in Branford
5 out of 5 average rating, 18 reviewsRiverview
Superhost

Cabin in McAlpin
4.79 out of 5 average rating, 39 reviews2 story Florida Cypress Cabin
Destinations to explore
- Seminole Vacation rentals
- Central Florida Vacation rentals
- Saint Johns River Vacation rentals
- Orlando Vacation rentals
- Florida Panhandle Vacation rentals
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- Charleston Vacation rentals
- Ginnie Springs
- Ichetucknee Springs State Park
- Gilchrist Blue Springs State Park
- Manatee Springs State Park
- Madison Blue Spring State Park
- Keaton Beach
- Shired Island Trail Beach
- Depot Park
- Ironwood Golf Course
- Fanning Springs State Park
- Florida Museum of Natural History
- Suwannee Country Club
- Horseshoe Beach Park
- Suwannee River State Park