Vacation rentals in Mesa County

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Top-rated vacation rentals in Mesa County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A hot tub is situated on a patio area, surrounded by a white fence. Two hanging egg chairs provide cozy seating. Soft landscape lighting reflects off the water, with a twilight sky featuring distant clouds and a colorful sunset in the background.
Home in Grand Junction
4.9 out of 5 average rating, 201 reviews

420Friendly_HotTub_12kGameArcade_WineBar_5Bed

✨This is 420 Friendly home and you are welcome to smoke and use any marijuana products you would like in the comfort of the house. (no tobacco) I provide smoking accessories that are clean and sanitized after each guest and kept safe in a kitchen cabinet out of reach of kids. Dogs are welcome with a $50 fee. ⭐Multiple Wineries ➡15 min drive ⭐Mesa University ➡5 min drive ⭐Airport➡ 5 min drive ⭐Downtown GrandJunction ➡8 min drive ⭐Amtrak Train Station➡10 min drive ⭐Palisade Orchards ➡15 min d

Guest favorite
A spacious living area features a large leather couch complemented by yellow and patterned cushions. Shelves display decorative items, while a modern flat-screen TV is mounted on a white wall. Natural light brightens the open layout, connecting to the kitchen and dining areas.
Home in Grand Junction
4.97 out of 5 average rating, 191 reviews

Resort-like Adobe At Colorado Monument!

This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

Top guest favorite
A covered porch is supported by wooden beams, featuring outdoor seating arranged on a textured rug. Large windows reflect the golden hour light, blending the indoor and outdoor spaces. Scenic views extend beyond the deck, highlighting the natural surroundings.
Guesthouse in Cedaredge
4.97 out of 5 average rating, 216 reviews

Yonder Mountain Retreat

A beautiful guesthouse on 5 acres a few miles north of the quaint town of Cedaredge. Multiple access points to the Grand Mesa, the ultimate outdoor playground for snowmobiling, hiking, motorcycling, ATVs, UTVs, fishing & hunting! Extra parking for motorcycles, ATVs, UTVs, or snowmobiles! YMR permits guests to bring one furbaby without pre-approval ($100 pet fee still applies). To bring more than one pet, pre-approval & addt’l. fees apply. One external security camera by the kitchen door.

Guest favorite
Home in Palisade
4.92 out of 5 average rating, 248 reviews

The Pali House - 10 Acres & Wine Country Views

Welcome to The Pali House, a recently renovated 2-bed, 2-bath retreat on 10 private acres in Palisade wine country. Panoramic views, wrap-around porch, king bed, and the best stargazing in Colorado. Five minutes to wineries and dining, 40 minutes to Powderhorn. Designed for travelers seeking space, privacy, and stunning Western Slope sunsets. The home is extra large for groups of 4 and is fully stoked with everything you need to make Palisade home for a trip away. Your hosts, Joe & Trish

Top guest favorite
A view displays the surrounding landscape featuring a prominent rock formation under a clear blue sky. The grassy area is complemented by a tree and well-maintained shrubs, while a quaint white house and adjacent structure frame the scene.
Tiny home in Palisade
4.99 out of 5 average rating, 370 reviews

Carriage House on Organic Peach Farm

Located on the Scenic Fruit & Wine Byway the Carriage House is on our organic three-acre peach farm within easy biking distance to downtown Palisade, surrounding wineries & hiking trails. Enjoy downtown Palisade's farmers market, distillery, brewery & restaurants. We're moments from many wineries & trailheads including access to The Plunge, Mt. Garfield, Palisade Rim & Riverbend Park. Begin, end or spend your day lounging in the little yard quaint for sipping wine & enjoying charcuterie.

Top guest favorite
The exterior of a rustic cabin is showcased, featuring a wooden façade with a gabled roof. A sign labeled 'GUNNISON' is affixed above the entrance. A wraparound deck and surrounding trees are visible, blending the structure harmoniously with the natural landscape.
Cabin in Paonia
4.96 out of 5 average rating, 262 reviews

Cozy Coyote Cabin

Please note! We are in the mountains and a 4WD vehicle is highly recommended for winter travel. Welcome to beautiful Paonia and your cozy and peaceful cabin getaway. Just 3.5 miles from the town of Paonia means you're oh-so-close yet so far away from it all. Stillness, beauty, and relaxation. If you're looking for a little cozy reconnect with nature and a disconnect from the rat-race, you've found it. The Coyote Cabin is perfect home base for exploring the abundant North Fork Valley.

Top guest favorite
A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.
Home in Loma
5 out of 5 average rating, 692 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Top guest favorite
An entrance area features a solid grey door surrounded by potted plants and flowers in various colors. A wooden table with floral arrangements and a decorative wall planter adds charm. Natural light enhances the inviting atmosphere, while a shady overhang provides shelter.
Guest suite in Paonia
4.98 out of 5 average rating, 331 reviews

Very spacious private floor with beautiful views.

Self check-in to the space makes it especially convenient for travelers no matter when you arrive. Views of the surrounding mountains are breathtaking.Our place is good for couples, solo adventurers, and business travelers. The space is on your own floor, completely separated from our upstairs space and with a private entrance. Enjoy a self-serve continental breakfast with freshly ground coffee and an assortment of teas. The location is quiet and private, yet so close to town.

Top guest favorite
Guesthouse in Palisade
4.99 out of 5 average rating, 165 reviews

Peach House. Private Tiny House. 1 bed, 1 bath.

The Peach House is a Tiny Home! Private parking, entrance and the entire tiny house is yours with a studio apartment vibe. Kitchenette (sink, coffee maker, toaster, fridge and microwave). Full bathroom with shower, double bed, TV and a comfy couch. Private outdoor patio, firepit and unobstructed view of Palisade vineyards, Mt. Garfield and Colorado sunsets. Tiny and set among the vines and peach orchards. Close to wineries, hiking, river activities and downtown Palisade.

Guest favorite
The exterior of a modern two-story villa is visible, featuring a combination of wood and stone materials. Large windows allow natural light to fill the interior, while a spacious front porch is supported by sturdy pillars. The surrounding landscape is open, highlighting the villa's secluded position.
Villa in Olathe
5 out of 5 average rating, 10 reviews

Secluded Crawford Villa with Hot Tub

Relax with the whole family or bring just a friend or two while you stay at one of our villas. Completed in 2022, our 2 bedroom, 2 bathroom villas include a flexible loft space, an open living room and fully equipped kitchen and a private hot tub and fire pit. Secluded yet conveniently located near BLM land, the Black Canyon and many other spectacular destinations near the city of Montrose, we are sure there is something to do for everyone when you stay at our villas.

Guest favorite
A modern house is set against a clear night sky filled with stars. The exterior features large glass doors, providing a seamless view of the surroundings. A spacious patio area is visible, bordered by natural landscaping, creating a sense of tranquility and connection to nature.
Home in Palisade
4.97 out of 5 average rating, 170 reviews

Rapid Creek Retreat

High above the town of Palisade, nestled in the foothills of the Grand Mesa, is the Rapid Creek Retreat. Surrounded by untouched public land you will experience the true gift and grit of Colorado. Enjoy views of the big sky from sunrise to sunset and beyond for magical star gazing. We planned for this home to be ours, every detail of this home was built with intent and love. The feeling here is truly special. For those ‘rough around the edges. Sincerely, The Busch’s

Top guest favorite
A two-story house is seen from the outdoor area, featuring a patio with several chairs and tables. A gravel driveway leads to lush vineyards in the background, framed by distant mountains under a clear blue sky.
Home in Palisade
5 out of 5 average rating, 143 reviews

Love Orchard

You will enjoy breathtaking endless views of orchards, vineyards and the Bookcliff mountains and amazing sunsets from the bright, open great room and balcony. You may think you are in the clouds! The peace and quiet you will feel in this lovely new home will surely refresh you. Located on the fruit and wine byway, there are 6 wineries within 3 miles yet you are only 2.5 miles from downtown Palisade and its plentiful offerings. This home is calling your name!

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