
Vacation rentals in Guadalupe
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Guadalupe
Guests agree: these stays are highly rated for location, cleanliness, and more.

Upstairs Guest Loft~EV Charge/Non-smoking/Pet-free
Private upstairs loft includes kitchenette, full bathroom, deck, and separate entrance. Grizzl-E Classic 40A EV Level 2 charger (Type 1/SAE J1772) with NEMA 14-50 and 6-50 plugs. Non-smoking, pet-free property. In the heart of CA's Central Coast between Los Angeles and San Francisco. Only 2 miles off Highway 101. Close to Pismo Beach, wineries, and golf at Monarch Dunes, Black Lake, and Cypress Ridge courses. Easy access for road trips, weekend getaways, and relaxing stays year-round. No AC.
LocationValueAmenities
4.94 out of 5 average rating, 873 reviews
Cozy Tiny House Near The Beach
Consider this studio your home away from home while you visit the BEAUTIFUL Central Coast. This cool and pleasant space features 1 queen bed in the bedroom and a cozy living room with a couch that can sleep an additional guest(s). The Living room and bedroom are equipped with 50-inch TV' connected to the Wi-Fi for YouTube etc. Enjoy the convenience of a shower, hair dryer, iron and Wi-Fi during your stay. The unit you will be staying in is equipped with a full kitchen. Dining table/Island for 2.
LocationValueBeach
4.85 out of 5 average rating, 65 reviews
The Loft at Callender Cove with private jacuzzi
As 26-time Superhosts, we invite you to rest and relax in comfort & style. This beautifully furnished, very clean upstairs apartment is quiet and decorated in calming beach decor. Enjoy the property's private jacuzzi by reservation and lovely upstairs views of the countryside and eucalyptus trees. Safe location with a separate, private entrance. Fully furnished with kitchen essentials including coffee maker, Brita filter, dishes, silverware, pots, pans etc. Not child friendly for many reasons.
FamilyLocationHiking
4.93 out of 5 average rating, 98 reviews
Pet Friendly, Centrally Located w/ Shared Gym
Welcome to The Jungalow, a beautiful 1 bed/1bath apartment style home nestled in the “Loft District'' of Santa Maria! This home features an inviting bedroom and a spacious living area with ample natural light. You are minutes away from the 101, shopping, and local restaurants. Santa Maria is centrally located, just an hour from Santa Barbara and about 30 mins from San Luis Obispo, Solvang & Chumash Casino! Enjoy being close to beautiful beaches, hiking trails, golf courses & renowned wineries.
ValueFamilyQuiet
4.9 out of 5 average rating, 105 reviews
OMG Playground, close to Beach, Family Fun
Relax near the coast at this Nautical Themed retreat! This peaceful home is in a conveniently located neighborhood. It's an updated 3 bedroom, 2 bath home, with modern features. The gem of this property is the backyard/ playground where your family will enjoy hours of fun. Backyard includes a converted Lifeguard Tower/ Treehouse, a Lighthouse Play Fort, Ball Pit, Trampoline, & Sand Box. The home is approx. 2 miles to Pismo State Beach and 2 blocks to shopping such as Starbuck's & Aldi.
LocationFamilyDecor
4.97 out of 5 average rating, 109 reviews
Modern Guest House, 20 Min. Pismo Beach & Wineries
Welcome to our beautiful 2-bedroom, 1-bathroom guest house in the heart of Santa Maria! Nestled in a safe residential neighborhood, our brand new construction guest house is the perfect retreat for families and friends looking to explore the local wineries and vineyards or simply enjoy some beach days. The guest house offers a prime location, minutes away from the 101 freeway, making it easily accessible for our guests. Book your stay with us today and let us exceed your expectations!
LocationValueCondition
4.84 out of 5 average rating, 105 reviews
Pet-Friendly 5 bdrm Home w/ Gym & Large Backyard
Welcome to Casita Santa Maria, your spacious home away from home in North Santa Maria! This expansive 5-bedroom, 2.5-bathroom home has all the space and comfort you need. While our home is a well-loved property with plenty of character, it has been fully refreshed with brand-new furnishings, plush mattresses, and crisp linens. Located in a safe, quiet residential neighborhood just 5 minutes off the freeway, so you perfectly positioned to explore all the Central Coast has to offer.
FamilyHospitalityComfort
5.0 out of 5 average rating, 5 reviews
Central Coast Gem: Lux 2BR/Sleep Number King Bed
Experience the ultimate Central Coast escape in this bright, upstairs sanctuary perfectly positioned between the rolling vineyards of Wine Country and the pristine sands of the Pacific. Whether you’re a family looking for a "home away from home", a couple seeking a high-end retreat, or a professional looking for a relaxing place to work, our sun-drenched 2BR unit offers the perfect blend of coastal charm and modern luxury with all the conveniences of home.
LocationFamilyAccess
4.92 out of 5 average rating, 25 reviews
Stunning Guesthouse with Private Entry & Courtyard
Welcome to our stunning, brand-new guesthouse—a serene and stylish 1-bedroom, 1-bath retreat designed to make your stay unforgettable. Located in Orcutt, CA, this cozy haven offers the perfect base for exploring the beauty of the Central Coast. Just a short drive from Santa Barbara (60 minutes), Pismo Beach (30 minutes), Vandenberg (25 min), and countless local attractions, this quiet neighborhood getaway is ideal for both leisure and business travelers.
FamilyHospitalityComfort
5.0 out of 5 average rating, 15 reviews
Home, comfortable to rest and relax. Welcome
Forget your worries in this spacious and serene space. In a quiet neighborhood where you can relax with your whole family, easy to find, near entrances and exits for the Freeway, very close to the shops where you can do your shopping easily. Everything is centrally located. No drugs are allowed in this home. If you break the rules, you will be immediately evicted from this home. If you meet the requirements. Welcome, thank you, and have a nice day!
FamilyValueAir conditioning
4.95 out of 5 average rating, 64 reviews
French Country Casita - Breakfast Included
This stand-alone casita sits in the privacy of our rear yard and has a separate entrance. We are three minutes from highway 101 in the newer La Ventana community. Surrounded by beautiful mountain views on the Central Coast and close to many flourishing wineries, this residence is 20 minutes south of Pismo Beach, 30 minutes from San Luis Obispo, one hour north of Santa Barbara, close to the beautiful Danish city of Solvang and Santa Ynez.
FamilyValueBathroom
4.99 out of 5 average rating, 1751 reviews
Sanctuary on Sunset Ridge ~ Panoramic Ocean Views
Enjoy extraordinary VIEWS, PEACE, and PRIVACY just 15 minutes from downtown and beaches. Within 10-15 minutes: Hiking, Biking, SUP, Kayaking, Surfing, Wine Tasting, Great Restaurants, etc., etc. We are good-dog friendly. 3-night minimum stay. We have 2 ensuite King bedrooms - the 2nd has a loft with a double bed. Check us out on Insta: @sanctuaryonsunsetridge
FamilyLocationGrill
4.96 out of 5 average rating, 153 reviewsPopular amenities for Guadalupe vacation rentals
Other great vacation rentals in Guadalupe

This apartment is located on the central coast
ValueLocationHospitality
4.85 out of 5 average rating, 85 reviews
Orchard Oasis: Pool Table, King Beds Ensuite Baths
LocationValueAccuracy
4.92 out of 5 average rating, 91 reviews
Hot Tub • Pool Table • Near Beach and Wineries
LocationFamilyKitchen
4.83 out of 5 average rating, 24 reviews
Entire Craftsman Home Central Coast Hub
ValueFamilyGrill
4.87 out of 5 average rating, 285 reviews
GORGEOUS HOME, BEACH, BBQ & WINE🌊🌴🍷🥂 RELAX & PLAY
LocationFamilyIndoor spaces
4.9 out of 5 average rating, 29 reviews
Nipomo Country Cottage
FamilyValueSleep quality
5.0 out of 5 average rating, 11 reviews
Classic Early 20th Century Farmhouse
ValueLocationWalkability
4.86 out of 5 average rating, 77 reviews
Wild Holly Retreat… walking distance to downtown
FamilyValueTV
4.71 out of 5 average rating, 290 reviewsDestinations to explore
- San Diego Vacation rentals
- Los Angeles Vacation rentals
- San Francisco Vacation rentals
- Big Bear Lake Vacation rentals
- Palm Springs Vacation rentals
- Tijuana Vacation rentals
- San Jose Vacation rentals
- Joshua Tree Vacation rentals
- Mammoth Lakes Vacation rentals
- Long Beach Vacation rentals
- Santa Barbara Vacation rentals
- West Hollywood Vacation rentals
- Cayucos Beach
- Pismo State Beach
- El Capitán State Beach
- Montaña de Oro State Park
- Morro Strand State Beach
- Los Padres National Forest
- Cayucos State Beach
- Morro Rock Beach
- California Polytechnic State University
- Dinosaur Caves Park
- Sensorio
- Mission San Luis Obispo de Tolosa
- Pismo Preserve
- Charles Paddock Zoo
- Monarch Butterfly Grove
- Vina Robles Amphitheatre
- Tablas Creek Vineyard
- Downtown City Park
- Nojoqui Falls Park
- Niner Wine Estates
- Solvang Windmill
- Talley Vineyards
- Harmony Headlands State Park
- Fess Parker Winery & Vineyard





